Mucosal and Systemic Immune Human Male Genital Tract Secretions: Both
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چکیده
منابع مشابه
Induction of mucosal immune responses in the human genital tract.
Mucosae of the female and male genital tracts are the portals of entry for sexually transmitted diseases (STDs) of viral, bacterial, and parasitic origin; worldwide, V120 000 000 cases of STDs are reported annually, but the true incidence is probably much higher. Infection with human immunode¢ciency virus (HIV) is no exception: epidemiologic data indicate that worldwide, 70^ 90% of all HIV infe...
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Herpes simplex virus (HSV) most frequently initiates infection at a mucosal surface; thus mucosal immune responses are likely to be important in defense against HSV infection. We have examined the effects of eliciting mucosal as well as systemic immune responses on protection against genital challenge infection with virulent HSV-2 in mice immunized with a replication-defective mutant of HSV-2. ...
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To generate a useful strategy for mucosal immunization, we have developed an approach of lipidating a multiple Ag peptide (MAP) containing part of the V3 loop from HIV-1 gp120IIIB. In this work, we compare two delivery systems, lipidated MAP in PBS and encapsulation in poly(DL-lactide-co-glycolide) microparticles. Subcutaneous immunization, followed by intragastric administration of MAP peptide...
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Attenuated strains of Salmonella are attractive live vaccine candidates for eliciting mucosal as well as systemic immune responses. The ability to induce immune responses in the reproductive tract may be critical for the effectiveness of a prophylactic vaccine against genital human papillomaviruses (HPV), which are important etiologic agents in the development of cervical cancer. To examine the...
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